Lineage Spatiotemporal Fragment Atlas
computational map of fragment interactions across aging-context nodes
Lineage Spatiotemporal Fragment Atlas
computational map of fragment interactions across aging-context nodes
TTR: approved RNAi precedent
TTR is an approved RNAi target-modulation external precedent only. Cellico Bio is not claiming a care program; TTR is an anchored reference node while Cellico Bio maps fragment-level review regions for downstream validation.
refs: dailymed-onpattro-patisiran, dailymed-amvuttra-vutrisiran, fda-rna-based-medicine-patisiran
Cellico Bio: fragment review-region search
Computational review region; validation required. The overlay marks where source-grounded fragment review sits across somatic and aging-context layers.
refs: No public citation required for schematic overlay
Aggregation-context comparators
IAPP, MAPT/tau, amyloid context, aging-context nodes, and oldest-old ATTRwt context orient the fragment-space layer. Optional prion-like context stays muted unless citation-gated.
refs: lehallier_2019, oh_2023, ding_2025_text_only, tanskanen_2008_ssa_very_aged, connors_2011_ssa_men, coles_young_2012_supercentenarian_ttr
Oldest-old ATTRwt context
Wild-type transthyretin amyloid is included as a somatic-endpoint context for the oldest old and for male-skewed late-life ATTRwt observations. This is context only, not a Cellico Bio TTR treatment or causality claim.
refs: tanskanen_2008_ssa_very_aged, connors_2011_ssa_men, coles_young_2012_supercentenarian_ttr
RNA accessibility / folding-ensemble context
Exploratory accessibility and folding-ensemble context only. The atlas does not equate RNA accessibility with a protein-state label.
refs: No public citation required for schematic overlay
Cellico Bio turns life-course context into governed review-region shortlisting.
A governed search system for finding source-grounded protein-fragment review regions worth downstream validation.
Byron P. Lee
Founder, Cellico Bio
Cellico Bio searches protein-fragment space for source-grounded review regions worth downstream validation.
Source-grounded computational triage of protein-fragment review regions.
I’m looking for scientific, translational, and company-building partners to pressure-test this governed fragment review-region search layer.
Sanity Checks & Acknowledgements
People who reviewed the framing, design, or communication for clarity.
People who reviewed the framing, design, or communication for clarity.
Elliot Roth
General Partner, Biopunk Community
Patrick Mellor
Nick Bayhi, Ph.D.
Jeff Yunes
Jon Beserra
Math sanity check
My own sanity check
Why I’m in longevity, in first person.
280 pounds lost since 2019 with prescription GLP-1s, gastric sleeve surgery, other prescriptions, PT, diet, and exercise.
80 of those pounds kept off since April 4, 2025 — the day I started Vitalist Bay and moved back to the Bay. Today's pitch is at Vitalist Bay 2026.
Losing or gaining weight is easy. The hard part is keeping it off forever. This is why I am into longevity.
— Byron P. Lee, Founder, Cellico Bio
Come swim or hot tub with me sometime.