Citations
TTR-targeted RNAi therapies (ONPATTRO/patisiran, AMVUTTRA/vutrisiran) are cited on this page as external approved precedent only. They are FDA-approved medicines developed by their respective sponsors. Cellico Bio does not manufacture, prescribe, or validate those therapies. Cellico Bio's contribution is a separate software and governance layer that performs source-grounded fragment review-region search across changing biological context. The TTR citations are included here because they anchor an external precedent that target-modulation of an amyloidogenic protein is achievable in humans; they are not a claim that Cellico Bio treats hATTR, performs RNAi, or modifies any disease. See /cellico/disclaimer for the full claim boundary.
Public-source references used by the Cellico Bio publication companion surfaces. Each entry names the canonical source and what the public page uses it for. No private Cellico Bio data, scorer internals, candidate identifiers, or row-level fragment data appear here or on any public surface.
- DATABASE_ENTRY
UniProt entry P37840 — human α-synuclein (SNCA)
Used for: Public protein identity, residue count, and region annotations (N-terminal amphipathic, NAC, C-terminal acidic) used by the /cellico/pipeline IDP structure-context and ensemble panels.
- DATABASE_REFERENCE_PAPER
UniProt: the Universal Protein Knowledgebase in 2025
Used for: Citation of the UniProt resource that supplies the public α-synuclein reference entry.
- DATABASE_ENTRY
RCSB PDB entry 9A1A — α-synuclein monomer ensemble structure
Used for: Public ensemble / integrative structure context for α-synuclein shown in the schematic IDP figures. Not used as a fixed-fold structure.
- PEER_REVIEWED_ARTICLE
The structural heterogeneity of α-synuclein is governed by several distinct subpopulations with interconversion times slower than milliseconds
Used for: Public-literature support for α-synuclein structural heterogeneity / ensemble framing referenced by the ensemble context panel.
- DATABASE_ENTRY
AlphaFold DB entry AF-P37840-F1 — computed model of α-synuclein
Used for: Source of per-residue pLDDT model confidence shown as a separate model-confidence layer. Not interpreted as a disorder probability.
- DATABASE_REFERENCE_PAPER
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
Used for: Citation of the AlphaFold Protein Structure Database that provides the AF-P37840-F1 model entry.
- PEER_REVIEWED_ARTICLE
Highly accurate protein structure prediction with AlphaFold
Used for: Method citation for the AlphaFold model and pLDDT confidence metric used as the model-confidence layer.
- PEER_REVIEWED_ARTICLE
Intrinsically Disordered Tardigrade Proteins Self-Assemble into Fibrous Gels in Response to Environmental Stress
Used for: Bridge-context citation for the tardigrade stress-protein context shown on the legacy /cellico/pitch walkthrough. Used as public literature context only — not a Cellico Bio validation result. The example protein name remains pending Cellico Bio source approval per the cellico-bio tardigrade example data contract.
- DATABASE_REFERENCE_PAPER
DisProt in 2024
Used for: Public reference for intrinsically disordered protein context. Used as background literature; no DisProt scores are rendered.
- REGULATORY_LABEL
DailyMed label — ONPATTRO (patisiran) lipid complex injection
Used for: External regulatory-label anchor for the TTR approved RNAi precedent node in the Lineage Spatiotemporal Fragment Atlas. It is not a Cellico Bio output.
- REGULATORY_LABEL
DailyMed label — AMVUTTRA (vutrisiran) injection
Used for: External regulatory-label anchor for RNAi target-modulation precedent around transthyretin. It is kept separate from Cellico Bio fragment review-region search.
- REGULATORY_LABEL
FDA CDER science article — RNA-based medicine
Used for: FDA public context for patisiran as an RNA-based medicine. The atlas uses this as external precedent only.
- PEER_REVIEWED_ARTICLE
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau
SourceDOI 10.1080/07853890701842988Used for: Text-citation context for oldest-old wild-type transthyretin amyloid / senile systemic amyloidosis placement near the somatic endpoint.
- PEER_REVIEWED_ARTICLE
Clinical features and survival in senile systemic amyloidosis: comparison to familial transthyretin cardiomyopathy
SourceDOI 10.3109/13506129.2011.574354059Used for: Text-citation context for male-skewed late-life wild-type transthyretin amyloid observations. Not a Cellico Bio treatment claim.
- PEER_REVIEWED_ARTICLE
Supercentenarians and transthyretin amyloidosis: the next frontier of human life extension
SourceDOI 10.1016/j.ypmed.2012.03.003Used for: Text-citation context for transthyretin amyloidosis in supercentenarian / extreme-old-age discussion. Not a longevity intervention claim.
- PEER_REVIEWED_ARTICLE
The serial cultivation of human diploid cell strains
Used for: Text-citation context for replicative limits in the Lineage Spatiotemporal Fragment Atlas. Not a Cellico Bio validation result.
- PEER_REVIEWED_ARTICLE
A proteomic atlas of senescence-associated secretomes for aging biomarker development
Used for: Text-citation context for the senescence module and SASP wording.
- PEER_REVIEWED_ARTICLE
The senescence-associated secretory phenotype: the dark side of tumor suppression
Used for: Text-citation context for senescence-associated secretory phenotype language.
- PEER_REVIEWED_ARTICLE
Cellular Senescence: Defining a Path Forward
Used for: Text-citation context for cellular senescence terminology and boundaries.
- PEER_REVIEWED_ARTICLE
Undulating changes in human plasma proteome profiles across the lifespan
Used for: Text-citation context for proteomic aging-wave references in the atlas.
- PEER_REVIEWED_ARTICLE
Organ aging signatures in the plasma proteome track health and disease
Used for: Text-citation context for organ and aging-state proteomic references.
- PEER_REVIEWED_ARTICLE
Proteomic aging atlas
Used for: Text-citation-only context for aging-wave language. Figure assets are not reused.
- PEER_REVIEWED_ARTICLE
The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease
Used for: Text-citation context for maternal mitochondrial inheritance framing.
- PEER_REVIEWED_ARTICLE
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
Used for: Text-citation context for long-lived protein references in aging-context layers.
- PEER_REVIEWED_ARTICLE
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
Used for: Caveat citation for immune-context wording; avoids simple inherited adult-immune-state claims.
- PEER_REVIEWED_ARTICLE
Immune mechanisms at the maternal-fetal interface: perspectives and challenges
Used for: Text-citation context for gestational immune-environment framing.
- PEER_REVIEWED_ARTICLE
Immunology of the maternal-fetal interface
Used for: Text-citation context for maternal-fetal immune tolerance language.
- PEER_REVIEWED_ARTICLE
Placental transfer of maternal antibodies
Used for: Text-citation context for maternal-antibody / early-life immune-context wording.
- PEER_REVIEWED_ARTICLE
The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness
Used for: Text-citation context for germ-line/soma framing in the atlas schematic.
- PEER_REVIEWED_ARTICLE
Oocyte long-lived proteins maintain fertility and embryonic development
SourceDOI 10.1038/s41556-024-01442-7Used for: Text-citation context for oocyte long-lived proteome labels. Local source-vault import pending.
- PEER_REVIEWED_ARTICLE
Oocyte macromolecule longevity context
SourceUsed for: Text-citation context for oocyte macromolecule longevity labels. Local source-vault import pending.
- PEER_REVIEWED_ARTICLE
Paternal contribution: new insights and future challenges
SourceDOI 10.1038/nrg1654Used for: Text-citation context for sperm contribution beyond DNA. Local source-vault import pending.
- PEER_REVIEWED_ARTICLE
Sperm perinuclear theca and protein cargo context
SourceUsed for: Text-citation context for sperm-borne protein cargo labels. Local source-vault import pending.
- PEER_REVIEWED_ARTICLE
Sperm factors and oocyte activation context
SourceDOI 10.1007/s10815-016-0653-0Used for: Text-citation context for sperm-side fertilization and activation labels. Local source-vault import pending.